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That is a problem for several reasons: GLP-1 medications carry boxed warnings about thyroid C-cell tumors in rodents and are contraindicated in people with a personal or family history of medullary thyroid carcinoma or MEN2
These hostmicrobe interactions have been extensively reviewed, highlighting a bidirectional regulatory axis in which GLP-1 signaling and microbial metabolites coordinate energy balance and immunemetabolic processes
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